In this case, the process of development of the Barrett’s
esophagus and the development of adenocarcinoma as a complication
of this disease with involvement of lymphoid tissue with the formation
of follicles of different types was studied. Barrett’s esophagus (BE) is
a precursor of adenocarcinoma of the esophagus, a disease with a
growing burden in the Western world. The incidence of BE increased
dramatically during the late 20th century and morbidity of these
disease increased as well. Prevalence is between 0.5 and 2.0%. There
are risk factors for BE including obesity and tobacco smoking, but
gastro-esophageal reflux disease (GERD) is the strongest risk factor.
Adenocarcinoma of the esophagus (ACE) is the most common form
of esophageal cancer. However, the data from United Kingdom and
the Netherlands show that the incidence of BE increased even after
monitoring the increase in endoscopy indices. These estimates indicate
an increase in the incidence of BE in approximately 65% between
1997 and 2002 and 159% between 1993 and 2005. It is disturbing that
the greatest proportionate increase in the diagnosis of BE was in
people younger than 60 years, which is consistent with other works
from Europe. In analyzing the literature relating to the intrinsic glands
of the esophagus and Barrett esophagus, concerned the esophagus’s
own glands and the presence of a large number of endocrine cells in
them. Kolycheva N.I., Bektayeva R.R. studied at ultramicroscopic level.
When studying the work on the lymphoid formations of the esophagus,
we can cite, concerning the lymphoid component of the esophagus.
At present, the source of lymphocyte infiltration into its own plate,
types of lymphoid formations, has not been studied. To study the
lymphoid noncapsular formations of the mucous membrane of Barrett’s
esophagus, biopsy specimens of Barrett’s esophagus were taken. Early
only the epithelium of the esophagus was studied, but there was no
evidence of a propria of the mucous membrane and lymphoid tissue.
The research focus. To study lymphoid noncapsular formations of the
mucous membrane of the Barrett’s esophagus.
The research methods and materials used. Bioptates of Barrett’s
esophagus were used in 19 patients. The material was fixed in neutral
formalin, the thickness of the cut was 7-8 micrometer, staining:
Hemotoxylin-Eosin. Histological studies and photomicrographs were
performed using a ”Leica” microscope.
Results. a) Postcapillary venules (High endothelial venules) are the
precursors of lymphoid formation in the esophageal mucosa. b) The
alteration goes along the gastric and intestinal type. c) The formation
of a noncapsular lymphoid tissue not peculiar to the esophagus (gutassociated
lymphoid tissue). d) In metaplasia, the esophagus becomes
a lymphoepithelial organ in the colonic and intestinal type.
Conclusions. In the discussion of the obtained material, it can be said
that intraepithelial leukocyte appears in the epithelium of Barrett’s
esophagus, its own plate is infiltrated with lymphocytes and follicles
are formed. Lymphocytes penetrate the postcapillary venules (insert)
through the wall, which recirculates the lymphocytes. From all that
has been said, it can be assumed that the lymphoid apparatus in
the Barrett’s esophagus is included in the lymphopoiesis system and
functions as its component part.